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Xeljanz is the brand name for the medication tofacitinib. It is a prescription drug that belongs to a class of medications called Janus kinase (JAK) inhibitors. Xeljanz is primarily used for the treatment of certain autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.Xeljanz helps reduce the activity of the immune system, which can be overactive in autoimmune diseases. This can lead to a reduction in inflammation, pain, and other symptoms associated with these conditions. .