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Lisinopril is a prescription medication that belongs to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is commonly prescribed to treat high blood pressure (hypertension), heart failure, and improve survival rates after a heart attack. Lisinopril works by inhibiting the action of ACE, an enzyme that plays a role in the production of a hormone called angiotensin II. By blocking the effects of angiotensin II, lisinopril helps relax and widen blood vessels, which leads to a reduction in blood pressure and improved blood flow. .