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Linzess is a prescription medication used for the treatment of certain digestive disorders. Its active ingredient is linaclotide, which belongs to a class of drugs called guanylate cyclase-C agonists. Linzess is primarily prescribed for two conditions: chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). It works by increasing the secretion of fluid in the intestines and promoting bowel movements, thus alleviating constipation. .