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Bonine is an over-the-counter medication that is commonly used to prevent and relieve motion sickness. The active ingredient in Bonine is meclizine hydrochloride, which belongs to a class of medications called antihistamines. Meclizine works by blocking the action of histamine, a substance in the body that is involved in triggering symptoms of motion sickness. It helps to reduce the sensitivity of the inner ear to motion, thus alleviating symptoms such as nausea, dizziness, and vomiting that can occur during travel or in situations where there is motion or imbalance.